Characteristics, cellular and molecular mechanisms of renal aging and nutritional intervention strategies / 中华老年医学杂志

Renal aging is a gradual process of degenerative changes in tissue structure and physiological function and is closely related to the occurrence and development of acute kidney injury(AKI)and chronic kidney disease(CKD). The cellular and molecular mechanisms of renal aging mainly include cellular senescence and reduced autophagy, and are regulated by nutritional factors.Promoting reasonable and moderate energy-and protein-restricted diets, strengthening the supervision of food additives and preservatives, cultivating safety awareness of residents, and strictly controlling the daily salt intake are potential nutritional intervention strategies to prevent and delay renal aging.Given the limited number of studies, there is an urgent need to further explore the effectiveness of the above strategies to provide a new evidence-based approach to formulating precise and feasible personalized nutritional intervention programs.

Cross-sectional survey of preoperative nutritional status of cardiac surgery patients in southwest China / 中华危重病急救医学

Objective:To investigate the preoperative nutritional status of cardiac surgery patients in southwest China, analyze the incidence and characteristics of nutritional risk, and provide basis for establishing a standardized individualized nutritional intervention program for cardiac surgery patients.Methods:A cross-sectional survey was conducted on the nutritional status and intervention status of preoperative patients in cardiac surgery department of 23 general hospitals in Yunnan, Guizhou, Sichuan and Chongqing districts. At 00: 00 on July 7, 2022, the patients aged > 18 years old in cardiac surgery departments of the above hospitals who planned to undergo surgical treatment were enrolled as the survey objects to investigate the nutritional status on July 6, 2022 (the survey date), including basic information (general information, nutrition indicators, etc.), nutrition screening and evaluation (nutrition risk screening and organ support, etc.), nutrition treatment (nutrition supplement methods and prescriptions, etc.) and nutrition awareness of medical staff.Results:The 126 questionnaires were collected, of which 125 were valid (99.2%). ① Basic information: of the 125 patients, 67 patients were male (53.6%) and 58 patients were female (46.4%). The age ranged from 19 years old to 86 years old, with an average of (53.13±14.74) years old. Body mass index (BMI) was (22.21±3.78) kg/m 2. The age and BMI of men were significantly higher than those of women [age (years old): 56.63±13.34 vs. 49.09±15.35, BMI (kg/m 2): 22.74±3.86 vs. 21.59±3.61, both P < 0.05]. Of the 125 patients, 75 had valvular disease and 50 were with non-valvular diseases, which mainly included congenital heart disease [19 cases (15.2%)], aortic dissection [13 cases (10.4%)], coronary heart disease [12 cases (9.6%)], etc. The course of disease was 0.5 hour to 36 years, of which 93 patients (74.4%) were more than 6 months and 32 patients (25.6%) were equal to or less than 6 months. The proportion of female patients with disease duration > 6 months was significantly higher than that of male patients [87.9% (51/58) vs. 62.7% (42/67), P < 0.01]. The basic diseases mainly included hypertension [38 cases (30.4%)], coronary heart disease [12 cases (9.6%)], diabetes [7 cases (5.6%)], chronic obstructive pulmonary disease [COPD, 6 cases (4.8%)], etc. Among 125 patients, total protein (TP) < 60 g/L in 24 cases (19.2%), albumin (Alb) < 40 g/L in 64 cases (51.2%), anemia [male hemoglobin (Hb) < 120 g/L, female Hb < 110 g/L] in 33 cases (26.4%). A total of 60 cases of prealbumin data were collected, of which 23 cases (38.3%) were less than 200 mg/L.② Nutrition screening and assessment: 33.6% of the 125 patients did not undergo routine nutrition screening after admission, including the provincial and municipal tertiary hospitals. Among the 83 patients undergoing nutritional screening, 41 (32.8%) were at nutritional risk. Further analysis of patients with nutritional risk showed that of the 41 patients, 20 were male (48.8%) and 21 were female (51.2%); 27 cases (65.9%) was with valvular diseases and 14 cases (34.1%) was with non-valvular diseases; the course of disease was more than 6 months in 30 cases (73.2%), and ≤ 6 months in 11 cases (26.7%). Statistical comparison of the above 83 patients showed that women, basic disease, long term-valvular disease, anemia, low TP, and low Alb before operation were more prone to innutrition. ③ Nutritional therapy: of the 125 patients, 5 were receiving mechanical ventilation (4.0%) and 2 were using vasoactive drugs (1.6%); there were 5 cases with gastrointestinal dysfunction (4.0%), mainly manifested as abdominal distension, abdominal pain, constipation and diarrhea. One patient was treated with enteral nutrition through gastric tube combined with parenteral nutrition support, 124 patients were fed orally, and an irregular phenomenon of injecting amino acid fat emulsion through peripheral vein in 2 patients. ④ Nutrition awareness of medical staff: 124 (99.2%) of the 125 patients had a nutrition department in their hospital; 71 cases (56.8%) received nutrition education, of which 37 cases (52.1%) were consulted by the nutrition department. Of all the cases, only 38 (30.4%) were consulted by the nutrition department, of which 1 (2.6%) did not receive nutrition education after consultation. Conclusions:At present, the incidence of preoperative malnutrition in patients undergoing cardiac surgery is high in southwest China. The incidence of malnutrition in patients with basic diseases, long term-valvular disease, low TP, low Alb and anemia before operation is higher, and the incidence of malnutrition is hidden in women. The course of disease of women is longer than that of men at the time of treatment, and malnutrition is more likely to occur. The attending physicians should pay attention to the above groups. It is necessary to establish a standardized individualized nutritional intervention program and apply it to actual clinical diagnosis and treatment, so as to ultimately improve the prognosis of patients undergoing cardiac surgery and increase the benefits of patients in treatment.

Recomendaciones basadas en la evidencia sobre la nutrición e hidratación en los últimos días de vida / Evidence-based recommendations on nutrition and hydration in the last days of life

Resumen: Introducción: Los cuidados paliativos en México son contemplados como una necesidad en todos los niveles de atención. La nutrición e hidratación en estos enfermos hacia sus últimos días de vida es controversial. Objetivo: Identificar las recomendaciones basadas en la evidencia sobre la nutrición e hidratación en los últimos días de vida. Material y métodos: Se realizó una búsqueda documental sobre la nutrición e hidratación hacia el final de la vida tomando como marco temporal las últimas horas y/o los últimos días de vida del enfermo en el contexto hospitalario. Resultados: Con los criterios de búsqueda seleccionados se identificaron 83 documentos. No se encontraron metaanálisis. Existen dos revisiones sistematizadas de la literatura, un ensayo clínico, cuatro guías de práctica clínica, cuatro reportes de caso y 17 revisiones. Se desglosan los resultados relevantes de lo seleccionado. Conclusiones: Se identifica que existen controversias de fondo sobre la alimentación al final de la vida. Sobre la hidratación existe cierto consenso. Es indispensable contar con un nutriólogo dentro de los servicios de cuidados paliativos de la Nación.

Abstract: Introduction: Palliative care in Mexico is considered a necessity at all levels of care. Nutrition and hydration in these patients towards the last days of life is controversial. Objective: To identify evidence-based recommendations on nutrition and hydration in the last days of life. Material and methods: A documentary search on nutrition and hydration towards the end of life was carried out taking as a time frame the last hours and/or the last days of life of the patient in the hospital context. Results: With the selected search criteria, 83 documents were identified. No meta-analyses were found. There are two systematized literature reviews, one clinical trial, four clinical practice guidelines, four case reports and 17 reviews. The relevant results of the selected documents are broken down. Conclusions: It is identified that there are fundamental controversies about feeding at the end of life. On hydration there is some consensus. It is essential to have a nutritionist within the palliative care services of the Nation.

Análisis de costo-efectividad de intervención nutricional temprana comparado con la atención de rutina en pacientes con riesgo nutricional

RESUMEN Introducción: La desnutrición hospitalaria es un proceso multicausal y de alta prevalencia. La intervención nutricional temprana mejora el pronóstico de los pacientes afectados y reduce los costos sanitarios. Objetivo: Estimar la diferencia de costo efectividad de la atención de rutina comparado con la intervención nutricional temprana, en pacientes en riesgo nutricional, en un Hospital Universitario de alta complejidad entre marzo y octubre de 2012. Materiales y métodos: Estudio de evaluación económica en 165 pacientes adultos hospitalizados de especialidades médicas y quirúrgicas. Se tomó como referencia la información de un estudio de intervención cuasi experimental realizado en el año 2012. Se estratificaran los pacientes de acuerdo a días de estancia hospitalaria, complicaciones y estado nutricional según grupo de intervención y se obtuvieron los costos sanitarios. Resultados: La mediana en el costo por paciente con complicaciones fue de US$ 3.950 en el grupo de intervención nutricional temprana comparado con US$ 5.301 por la atención de rutina; para la estancia hospitalaria fue de US$ 2.462 vs US$ 4.201 y para los recursos derivados de optimización del peso fue de US$ 3.627 vs US$ 5.132 respectivamente. Conclusión: La intervención nutricional temprana en los pacientes en riesgo nutricional, disminuyó los costos derivados de complicaciones, estancia hospitalaria y optimización del estado nutricional.

ABSTRACT Introduction: Hospital malnutrition is a highly prevalent process with multiple causes. Early nutritional intervention improves the prognosis of affected patients and reduces health costs. Objective: To estimate the cost-effectiveness of routine care compared with early nutritional intervention, in patients at nutritional risk, in a high complexity university hospital between March and October 2012. Materials and methods: Economic evaluation study in 165 adult hospitalized medical and surgical specialty patients. The information from a quasi-experimental intervention study conducted in 2012 was taken as a reference. Patients were stratified by intervention group according to days of hospital stay, complications and nutritional status; health costs were also obtained. Results: For the early nutritional intervention group compared to routine care, the median cost per patient with complications was US$ 3,950 vs US$ 5,301; US$ 2,462 vs US$ 4,201 for hospital stay and US$ 3,627 vs US$ 5,132 for resources derived from weight optimization, respectively. Conclusion: The early nutritional intervention in patients at nutritional risk, decreased the costs derived from complications, hospital stay, and optimization of nutritional status.

Impacto da avaliação nutricional precoce e intervenção em pacientes com cirrose hepática / Evaluating the impact of early nutritional assessment and intervention in hospitalized liver cirrhosis patients

ABSTRACT Background Malnutrition is common in liver cirrhosis patients that is correlated with early complications, morbidity and mortality. Objective The purpose of the study was to assess nutritional status, impact of nutritional screening and intervention in liver cirrhosis patients by evaluating their actual energy and protein intake during hospital stay. Methods A cross sectional study was conducted wherein all patients' nutritional status was defined by Subjective Global Assessment tool. Adequate energy and protein supply were planned and executed by using individualized nutritional plan for patients with dietitian's collaboration. Anthropometric measurements included height, weight, body mass index, mid upper arm circumference, hand grip strength and triceps skin-fold thickness. Biochemical tests included haemoglobin, mean corpuscular haemoglobin, volume and concentration, albumin and liver function tests. To record the daily food intake, a 24-hour dietary recall was used. Results Overall 83 patients (mean age 55) were included, among them 46% of patients were moderately malnourished, 12% were normal, while 42% of cirrhotic patients were severely depleted according to Subjective Global Assessment. The mean intake of calories and protein was improved during stay in hospital after nutritional intervention and critical monitoring (P<0.05). Anthropometric measurements at baseline and discharge showed significant differences (P <0.05) in weight, body mass index, triceps skin fold thickness and mid upper arm circumference values, but not in hand grip strength that was associated with malnourishment among patients. Conclusion Providing individualized nutritional intervention and its monitoring by qualified dietitians during hospital stay helps to improve intake in patients that prevent further risk of malnutrition and related complications.

RESUMO Contexto A desnutrição é comum em pacientes com cirrose hepática e está correlacionada com complicações precoces, morbidade e mortalidade. Objetivo O objetivo do estudo foi avaliar o estado nutricional, o impacto da triagem nutricional e a intervenção em pacientes com cirrose hepática, avaliando sua ingestão real de energia e proteína durante a internação hospitalar. Métodos Foi realizado um estudo transversal em que o estado nutricional de todos os pacientes foi definido pela ferramenta de Avaliação Global Subjetiva. O fornecimento adequado de energia e proteína foi planejado e executado por meio de plano nutricional individualizado para pacientes com colaboração de nutricionista. As medidas antropométricas incluíram: altura, peso, índice de massa corporal, circunferência do braço médio, força de aderência da mão e espessura da dobra da pele tríceps. Os testes bioquímicos incluíram: hemoglobina, volume e concentração da hemoglobina corpuscular média, albumina e testes de função hepática. Para registrar a ingestão diária de alimentos, foi utilizado um recall dietético de 24 horas. Resultados Ao todo foram incluídos 83 pacientes (média de 55 anos), entre eles 46% dos pacientes estavam moderadamente desnutridos, 12% estavam normais, enquanto 42% dos pacientes cirróticos estavam severamente depletados de acordo com a Avaliação Global Subjetiva. A ingestão média de calorias e proteínas foi melhorada durante a internação hospitalar após intervenção nutricional e monitoramento crítico (P<0,05). As medidas antropométricas na linha de base e descarga apresentaram diferenças significativas (P< 0,05) em peso, índice de massa corporal, espessura da dobra da pele do tríceps e valores médios de circunferência do braço, mas não na força de aderência da mão que estava associada à desnutrição entre os pacientes. Conclusão Proporcionar intervenção nutricional individualizada e seu acompanhamento por nutricionistas qualificados durante a internação hospitalar ajuda a melhorar a ingestão em pacientes que previnem maior risco de desnutrição e complicações relacionadas.

A study on personalized nutritional intervention based on nutritional assessment in long-term continuous nursing for elderly postoperative colorectal cancer patients / 中华临床营养杂志

Object:To explore the role of personalized nutritional intervention based on nutritional assessment in long-term continuous nursing of elderly postoperative colorectal cancer patients.Methods:Elderly patients with colorectal cancer who received radical surgery in a tertiary hospital in Beijing were screened from January 2021 to January 2022 and a total of 100 patients at nutritional risk (defined as with a Nutritional Risk Screening 2002 [NRS 2002] score ≥ 3) were included in the study. Patients were stratified by age and then divided into control and intervention groups with 50 cases in each. The control group received regular health guidance and follow-up visits at postoperative outpatient clinics while the intervention group received personalized nutritional intervention based on nutritional assessment additionally. The intervention period was 12 months. Nutritional indicators including body mass index (BMI), upper arm circumference, grip strength and hemoglobin, as well as albumin and quality of life (QoL), are compared between the two groups.Results:Compared with the control group, the intervention group showed significantly better results of BMI [(18.46±0.53) vs (16.9±0.77)], upper arm circumference [(25.09±1.41)cm vs (23.49±1.45)cm], grip strength [(28.34±8.00)kg vs (23.97±7.19)kg], HGB [(135.10±9.27)g/L vs (106.40±8.73)g/L] and ALB [(41.62±3.41)g/L vs (28.62±2.38)g/L, all P < 0.01]. The intervention group also had significantly higher scores in physical [(20.96±2.03) vs (15.66±0.82)], emotional [(21.48±1.64) vs (15.76±1.00)], social [(23.44±1.67) vs (15.96±0.99)], and functional [(20.74±1.74) vs (5.46±0.97)] domains of QoL (all P<0.01). Conclusion:In elderly patients with colorectal cancer after radical resection, personalized nutritional intervention based on nutritional assessment can effectively control nutritional indicators, help reduce the incidence of malnutrition, improve postoperative quality of life, and inform the establishment of standardized process in nutrition management.

Influence of perioperative oral nutritional supplementation on short-term efficacy of laparos-copic sleeve gastrectomy for obesity patients: a prospective study / 中华消化外科杂志

Objective:To investigate the influence of perioperative oral nutritional supple-mentation on short-term efficacy of laparoscopic sleeve gastrectomy (LSG) for obesity patients.Methods:The prospective study was conducted. The clinical data of 218 obesity patients who underwent LSG in the General Hospital of Ningxia Medical University from January 2018 to December 2021 were selected. Patients receiving perioperative oral nutritional supplementation were allocated into the experiment group, and patients receiving perioperative conventional treatment were allo-cated into the control group, respectively. Observation indicators: (1) grouping situations of the enrolled patients; (2) postoperative situations and follow-up; (3) nutrition related indicators; (4) dietary compliance; (5) weight loss related indicators. Follow-up was conducted using telephone interview, WeChat communication and outpatient examination to detect albumin (ALB), hemoglobin (HB), dietary compliance and weight loss related indicators of patients up to February 2022. Patients were followed up once every 30 days after discharge. Measurement data with normal distribution were represented as Mean± SD, and comparison between groups was conducted using the indepen-dent sample t test. Measurement data with skewed distribution were represented as M(range), and comparison between groups was conducted using the Mann-Whitney U test. Count data were described as absolute numbers or percentages, and comparison between groups was performed using the chi-square test. Repeated measurement data were analyzed using the repeated ANOVA. Comparison of ordinal data was analyzed using the rank sum test. Results:(1) Grouping situations of the enrolled patients. A total of 218 patients were selected for eligibility. There were 42 males and 176 females, aged (32±9)years with body mass index (BMI) as (39±7)kg/m 2. Of the 218 patients, there were 109 patients in the experiment group and 109 patients in the control group. Gender(male, female), age, BMI, preoperative albumin (Alb), preoperative hemoglobin (Hb) were 17, 92, (33±9)years, (39±7)kg/m 2, (40.6±4.8)g/L, (141.7±13.9)g/L in the experiment group, versus 25, 84, (31±8)years, (39±8)kg/m 2, (40.9±4.2)g/L, (142.9±9.7)g/L in the control group, showing no signifi-cant difference in the above indicators between the two groups ( χ2=1.89, t=?1.52, 0.51, 0.40, 0.71, P>0.05). (2) Postoperative situations and follow-up. The duration of initial hospital stay, the cost of initial hospital stay were (9.1±2.9)days, (3.6±0.5)ten thousand yuan in the experiment group, versus(11.6±3.7)days, (4.9±1.0)ten thousand yuan in the control group,showing significant differences in the above indicators between the two groups ( t=5.58, 12.38, P<0.05). Of the 218 patients,119 patients were followed up,including 62 patients in the experiment group and 57 patients in the control group,with the follow up time as 31.0(range, 25.0?38.0)days. Of the 218 patients, 14 cases were read-mitted for postoperative complications. There were 2 cases in the experiment group including 1 case with nausea and vomiting and 1 case with ileus, and there were 12 cases in the control group including 10 cases with nausea and vomiting and 2 cases with gastric fistula. There was a significant difference in the readmission between the two groups ( χ2=7.63, P<0.05). The interval between readmission and initial discharge of the 14 patients was(22.0±6.7)days. (3) Nutrition related indica-tors. The Alb and Hb of the 62 patients being followed up in the experiment group were (40.4±5.5)g/L, (35.9±3.8)g/L, (45.4±2.9)g/L and (140.8±13.9)g/L, (130.5±16.9)g/L, (147.8±17.2)g/L before opera-tion, before the first discharge and one month after operation, respectively. The above indicators of the 57 patients being followed up in the control group were (41.2±3.9)g/L, (34.2±3.9)g/L, (42.7±5.3)g/L and (143.0±9.7)g/L, (122.9±12.8)g/L, (139.0±11.4)g/L before operation, before the first discharge and one month after operation, respectively. There were significant differences in change trends of Alb and Hb before operation to one month after operation between the two groups ( Fgroup=4.27, 5.72, P<0.05). There were significant differences in Alb and Hb before operation to one month after operation between the two groups ( Ftime=187.46, 85.13, P<0.05). There were interaction effects in change trends of Alb and Hb before operation to one month after operation between the two groups ( Finteraction=7.25, 9.13, P<0.05). Results of individual effect shown that there was no significant difference in the intervention effect of Alb and Hb before operation between the two groups ( t=?0.90, ?0.99, P>0.05), and there were significant differences in the intervention effect of Alb and Hb before the first discharge and one month after operation ( t=2.45, 3.34, 2.75, 3.34, P<0.05). (4) Dietary compliance. Cases with dietary complete compliance, partial compliance, non-compliance of the 62 patients being followed up in the experiment group were 28, 19, 15, respectively. The above indicators of the 57 patients being followed up in the control group were 17, 16, 24, respectively. There was a signifi-cant difference in the dietary compliance between the two groups ( Z=?2.14, P<0.05). (5) Weight loss related indicators. The body mass, body fat mass, skeletal muscle mass, body fat ratio, waist hip fat ratio, visceral fat area of the 62 patients being followed up in the experiment group were (111.0±23.0)kg, (50.0±15.0)kg, (34.0±7.0)kg, 45%±6%, 0.99±0.08, (178±53)cm 2, respectively, before opera-tion. The above indicators of the 57 patients being followed up in the control group were (108.0±22.0)kg, (49.0±13.0)kg, (33.0±7.0)kg, 45%±5%, 0.98±0.09, (174±51)cm 2, respectively, before opera-tion. There was no significant difference in the above indicators between the two groups ( t=?0.71, ?0.48, ?1.04, 0.70, ?0.80, ?0.46, P>0.05). The body mass loss, body fat mass loss, skeletal muscle mass loss, body fat ratio loss, waist hip fat ratio loss, visceral fat area loss of the 62 patients being followed up in the experiment group were 13.8(range, 11.8?16.5)kg, 7.5(range, 6.3?10.1)kg, 3.4(range, 2.5?4.6)kg, 2.05%(range, 1.19%?3.21%), 0.04(range, 0.03?0.06), 31.5(range, 24.4?41.0)cm 2, respectively, one month after operation. The above indicators of the 57 patients being followed up in the control group were 10.8(range, 8.5?13.1)kg, 5.9(range, 4.8?8.0)kg, 4.0(range, 3.0?5.2)kg, 2.0%(range, 0.75%?3.20%), 0.04(range, 0.03?0.05), 29.1(range, 21.8?37.9)cm 2, respectively, one month after operation. There were significant differences in the body mass loss and body fat mass loss between the two groups ( Z=?4.99, ?3.54, P<0.05), and there was no significant difference in skeletal muscle mass loss, body fat ratio loss, waist hip fat ratio loss, visceral fat area loss between the two groups ( P>0.05). Conclusion:Perioperative supplement of oral nutritional can reduce the incidence of post-operative complications and readmission and enhance the postoperative nutritional status and short-term efficacy of obesity patients undergoing LSG.

Effects of Nutritional Intervention on Nutritional Status and Quality of Life of Patients with Colorectal Cancer Treated with Postoperative Adjuvant Chemotherapy / 肿瘤防治研究

Objective To explore the effects of nutritional intervention on the quality of life and nutritional status of patients with colorectal cancer treated with postoperative adjuvant chemotherapy. Methods Fifty-six patients with colorectal cancer subjected to postoperative chemotherapy were selected. They were divided into nutritional intervention group (n=20) and control group (n=36). Blood test indices, PG-SGA scores, and 36-Item Short Form Health Survey scores were compared 4 weeks after the surgery. Results No significant difference in PG-SGA score was found between the nutritional group and the control group at admission (t=-0.347, P=0.730), but statistically significant difference was detected after 4 weeks (t=-2.708, P=0.009). At 4 weeks after the surgery, the serum levels of prealbumin, albumin, and hemoglobin were not significantly different between the two groups (P > 0.05). Other indices of quality of life assessment (P < 0.05), except for the index of emotional function (P=0.083), were significantly different between the two groups, and the scores of the nutritional intervention group were higher than those of the control group. Conclusion Nutritional intervention can effectively improve the nutritional status and quality of life of patients with colorectal cancer treated with postoperative adjuvant chemotherapy.

Guidelines for diagnosis and nutritional intervention of mild to moderate non-IgE mediated cow′s milk protein allergy in Chinese infants / 中华实用儿科临床杂志

Cow′s milk protein allergy (CMPA) is one of the most common presentations of food allergy seen in early childhood.It is an abnormal immune response caused by cow′s milk protein.CMPA can be clinically subdivided into either immediate-onset IgE mediated or delayed onset non-IgE mediated, or both.At present, concerns regarding the early and timely diagnosis of CMPA have been high-lighted over the years and there are many expert consensus on CMPA in China, but these consensus did not distinguish IgE mediated or non-IgE mediated CMPA.In view of the obvious clinical differences between the two type of CMPA and non-IgE mediated CMPA is more common in infancy, experts focus on pediatric gastroenterology, allergy/immunology, dermatology, nutrition and child healthcare convened by the Allergy Prevention and Control Professional Committee of Chinese Preventive Medicine Association present this guideline to help practitioners in primary care settings to early recognize and make suitable management of non-IgE mediated CMPA in China.The guideline incorporates the cutting-edge international guidance and the actual situation of Chinese children describing in detail the types, clinical features, diagnosis and nutritional intervention of non-IgE mediated CMPA.There are 42 recommendations in 7 categories in total referring to the common questions related to non-IgE mediated CMPA.

Research progress on the mechanism of nutritional intervention in the progression of metabolic-associated fatty liver disease / 公共卫生与预防医学

Metabolic-associated fatty liver disease (MAFLD) is considered as a multifactorial disease including genetic, physiological, and environmental factors, in which different factors overlap in various pathways, leading to metabolic impairment and liver damage. The main risk factors for MAFLD are overweight/obesity, insulin resistance/type 2 diabetes, hypertriglyceridemia and related dietary behaviors, mainly the intake of fructose beverages. Adherence to the Mediterranean diet is an important predictor of changes in liver fat content in patients with MAFLD. There is increasing evidence that prescribing specific supplements or nutraceuticals that have been proven to have hepatoprotective effects for MAFLD patients can accelerate the improvement of liver enzymes and liver steatosis or might prevent or delay the progression of MAFLD disease.

Impact of nutritional and physical activity interventions on the cognitive and academic achievement of schoolchildren

The objective of this review is to present the impact of nutritional education, physical activity and support network interventions on the nutritional status, cognitive and academic achievement of students under 18 years of age. According to the literature, multicomponent interventions that address diet, physical activity, and involve parents concluded to be more effective in combating obesity and enhancing academic achievement in young people. Therefore, the implementation of public policies that commit to intervene in a timely manner in the first stages of the life cycle, would have a considerably beneficial impact on health(AU)

El objetivo de esta revisión es dar a conocer el impacto de las intervenciones de educación nutricional, actividad física y redes de apoyo en el estado nutricional, rendimiento cognitivo y académico de estudiantes menores de 18 años. De acuerdo con la literatura, las intervenciones de carácter multicomponente que abordan alimentación, actividad física, e involucran a los padres concluyeron ser más efectivas para combatir la obesidad y potenciar el rendimiento académico en jóvenes. Por lo tanto, la implementación de políticas públicas que permitan intervenir de forma oportuna las primeras etapas del ciclo vital, tendrían un impacto considerablemente beneficioso para la salud(AU)

Association between stages of change regarding weight reduction in patients with cardiovascular risk factors: A randomized controlled trial

ABSTRACT Background: There is very low-quality evidence that the transtheoretical stages of change model combined with physical activity or diet, or both, can result in significant improvements in dietary and physical activity habits. Objective: To evaluate the association between stages of change on weight reduction, after a nutritional intervention, in patients with cardiovascular risk. Methods: In a randomized controlled clinical trial, patients >18 years old with body mass index ≥25 kg/m2 and at least two cardiovascular risk factors were distributed to an intervention or control group. The intervention group received, according to stage of change, a multidisciplinary intervention formed by a nutritionist, a psychologist, a chef and a physiotherapist to improve healthy eating, while the control group was given a nutritional prescription. Stage of change from the transtheoretical model, anthropometric variables, physical activity, and 24-hour recall of food intake were measured at baseline and 12 months postintervention. The main outcomes were change in weight, waist and hip circumferences. Results: We included 188 subjects (intervention group= 93, control group= 95), where 75% were female, 68.6% had obesity, and mean age 50.3±13. After 12-months, subjects in the intervention group that were ready to change showed a greater decrease in weight and energy intake, with differences between ready to change vs not ready to change subjects and an interaction between intervention group and ready to change. Conclusions: An intervention with a multidisciplinary team can be as effective as the current standard of care in promoting weight loss when taking into account baseline stage of change.

RESUMEN Introducción: existe poca evidencia sobre el efecto de la etapa de cambio del modelo transteórico en conjunto con actividad física, dieta, o ambas, en los hábitos dietéticos y de actividad física. Objetivo: evaluar el efecto de una intervención nutricional y la etapa de cambio inicial sobre la reducción de peso después de una intervención nutricional en pacientes con riesgo cardiovascular. Métodos: Ensayo clínico controlado aleatorizado. Pacientes >18 años con índice de masa corporal ≥25 kg/m2 y al menos 2 factores de riesgo cardiovascular fueron asignados a: grupo intervención o grupo control. El grupo de intervención recibió de acuerdo a la etapa de cambio una intervención multidisciplinaria formada por: nutricionista, psicólogo, chef y fisioterapeuta, mientras que el grupo control solo recibió prescripción nutricional habitual. Se evaluaron al inicio del estudio y 12 meses después de la intervención: etapa de cambio del modelo transteórico, variables antropométricas, actividad física y recordatorio de 24 horas. Resultados: se incluyeron 188 sujetos (grupo intervención 93, grupo control 95), 75% eran mujeres, 68,6% tenían obesidad, con promedio de 50.3±13. Después de 12 meses, los sujetos en el grupo de intervención que estaban listos para el cambio, mostraron una mayor disminución en el peso y en el consumo calórico, con diferencias estadísticamente significativas en la interacción grupo y etapa de cambio. Conclusiones: Una intervención con un equipo multidisciplinario puede ser tan eficaz como el tratamiento habitual para promover la pérdida de peso cuando se tiene en cuenta la etapa de cambio basal.

Evolução do consumo de nutrientes e de alimentos segundo a classificação NOVA em frequentadores de serviço de promoção da saúde da atenção primária / Evolution of nutrient and food consumption according to the NOVA classification among users of health promotion service in primary health care

INTRODUÇÃO: Consumir alimentos in natura, minimamente processados e preparações culinárias (PC), em detrimento aos ultraprocessados (AUP), pode melhorar o perfil nutricional da dieta e reduzir o risco de desenvolvimento de doenças crônicas não transmissíveis (DCNT). OBJETIVO: Avaliar a evolução do consumo de nutrientes e de alimentos, segundo a classificação NOVA, após intervenção coletiva de incentivo ao consumo de frutas e hortaliças (FH) em usuários do Programa Academia da Saúde (PAS) de Belo Horizonte, Minas Gerais. MÉTODOS: Foram desenvolvidos três artigos com dados oriundos de ensaio comunitário controlado e randomizado (ECCR), conduzido entre 2013 ­ 2015, com amostra representativa das unidades do PAS de Belo Horizonte, sendo 9 unidades pertencentes ao Grupo Controle (GC) e 9 ao Grupo Intervenção (GI). Indivíduos alocados no GC participaram das atividades rotineiras do serviço de saúde (prática regular de exercícios físicos três vezes/semana) e aqueles do GI adicionalmente receberam, durante sete meses, intervenção de incentivo ao consumo de FH, pautada no Modelo Transteórico e na pedagogia dialógica e problematizadora de Paulo Freire. Artigo 1: Estudo transversal realizado com dados da linha de base do ECCR que objetivou analisar o consumo de AUP segundo fatores sociodemográficos, e sua associação com o perfil nutricional da dieta. O perfil nutricional da dieta foi analisado segundo os quintis de contribuição percentual de energia oriunda de AUP mediante análises de associação e de Regressão Linear referente ao consumo de energia total, densidade energética, carboidratos, fibras, proteínas, gorduras totais e subgrupos de gorduras: saturada, monoinsaturada, poli-insaturada, trans, ômega 3 e ômega 6, vitaminas A, B3, B6, B12, Folato e C; e os minerais cálcio, ferro, fósforo, magnésio, potássio e sódio. Além disso, avaliou-se o percentual de inadequação do consumo de nutrientes recomendados para prevenção de DCNT e do consumo de vitaminas por Regressão de Poisson. Artigo 2: ECCR que objetivou verificar a efetividade de intervenção coletiva de incentivo ao consumo de FH sobre o consumo de alimentos, segundo a classificação NOVA, em frequentadores de serviço de promoção da saúde da Atenção Primária em Saúde (APS) brasileira. Os desfechos analisados foram consumo de PC, de alimentos processados (AP) e de AUP por meio de análises de associação e de comparação entre GC e GI, e Equações de Estimações Generalizadas (GEE). Artigo 3: ECCR que objetivou verificar a efetividade de intervenção coletiva de incentivo ao consumo de FH sobre a adequação do consumo de nutrientes, especialmente aqueles voltados para prevenção de DCNT, em frequentadores de serviço de promoção da saúde da APS brasileira. Também foram utilizadas análises de associação e GEE entre os grupos GI e GC. Os nutrientes analisados foram: energia total, carboidratos, fibras, proteínas, gorduras totais e subgrupos de gorduras: saturada, monoinsaturada, poli-insaturada, trans, ômega 3 e ômega 6, vitaminas A, B1, B2, B3, B6, B12, Folato, C, D, E; e os minerais cálcio, ferro, fósforo, magnésio, manganês, potássio, selênio, sódio e zinco. RESULTADOS - Artigo 1: O consumo de AUP contribuiu com 27,7% da energia total da dieta. O seu maior consumo associou a maiores valores de ingestão de energia, densidade de energia, gorduras totais e sódio; e menores de proteínas, gorduras monoinsaturadas, ômega 3 e algumas vitaminas e minerais. A prevalência de inadequação de nutrientes para prevenção de DCNT variou entre 30% e 100% entre o menor e maior quintil de consumo de AUP. Artigo 2: Após 12 meses de acompanhamento, observou-se entre os indivíduos do GI e do GC, aumento no consumo de PC e redução de AUP; além de aumento no consumo de AP entre os indivíduos do GC. Foi observado que a intervenção nutricional contribuiu para redução do consumo de AP para indivíduos alocados no primeiro quartil (RR: 0.861; CI: 0.749; 0.988) e aumento para aqueles alocados no segundo quartil de consumo de AP (RR: 1.145; CI: 1.041; 1.259). Também foi observada relação entre participação na intervenção nutricional e aumento do consumo de AUP para indivíduos alocados no terceiro quartil de consumo de AUP (RR: 1,062; CI: 1,005; 1,122). Artigo 3: Participantes dos grupos GC e GI, após 12 meses, apresentaram redução no consumo de energia, ômega 6 e sódio; e aumento de carboidratos, fibras, vitaminas A, B1, B2, B3, B6, B12, C, D e E, folato, cálcio, magnésio, potássio, selênio, manganês, zinco e ferro. Indivíduos do GC relataram ainda aumento do consumo de fósforo; e aqueles do GI, redução do consumo de gorduras totais, saturadas e poli-insaturadas; e aumento de monoinsaturadas. Em ambos os grupos, observou-se aumento na prevalência de adequação de nutrientes para prevenção de DCNT, exceto para gorduras trans. A participação na intervenção nutricional mostrou relação inversa com o consumo de energia (RR: 0,979; CI: 0,960; 0,999) e proteínas (RR: 0,978; CI: 0,959; 0,997) da dieta, mas não aumentou a chance de adequação dos demais nutrientes, incluindo aqueles voltados para prevenção de DCNT. CONCLUSÃO: Os resultados apontaram para a importância do PAS, um serviço de promoção da saúde do Sistema Único de Saúde, para a promoção da alimentação adequada e saudável, e prevenção das DCNT. A condução de intervenção coletiva de incentivo ao consumo de FH apresentou poucos resultados adicionais, evidenciando a necessidade de se realizar abordagens específicas relativas à classificação NOVA de alimentos visando alcançar melhores resultados.

INTRODUCTION: Consuming fresh, minimally processed foods and culinary preparations (CP), in detriment to ultra-processed foods (UPF), can improve the nutritional profile of the diet and reduce the risk of developing chronic non-communicable diseases (NCD). OBJECTIVE: Evaluating the evolution of nutrient and food consumption, according to the NOVA classification, after conducting a collective intervention to encourage the consumption of fruits and vegetables (FV) among users of the Health Academy Program (Programa Academia da Saúde - PAS) in Belo Horizonte, Minas Gerais. METHODS: Three articles were developed with data from a randomized controlled community trial (ECCR), conducted between 2013 and 2015, with a representative sample of the PAS units in Belo Horizonte, with 9 units belonging to the Control Group (CG) and 9 to the Intervention Group (IG). Individuals allocated to the CG participated in the routine activities of the health service (regular practice of physical exercise three times/week) and those in the IG additionally received, for seven months, an intervention to encourage the consumption of FV, based on the Transtheoretical Model and on the dialogical and problematizing pedagogy of Paulo Freire. Article 1: Cross-sectional study carried out with baseline data from the ECCR, which aimed to analyze the consumption of UPF according to sociodemographic factors, and its association with the nutritional profile of the diet. The nutritional profile of the diet was analyzed according to the quintiles of percentage contribution of energy from UPF through association and Linear Regression analyzes regarding total energy consumption, energy density, carbohydrates, fiber, proteins, total fat and fat subgroups: saturated, monounsaturated, polyunsaturated, trans, omega 3 and omega 6, vitamins A, B3, B6, B12, folate and C; and the minerals calcium, iron, phosphorus, magnesium, potassium and sodium. In addition, the percentage of inadequate consumption of nutrients recommended for the NCD prevention and the consumption of vitamins were evaluated by Poisson Regression. Article 2: ECCR which aimed to verify the effectiveness of collective intervention to encourage the consumption of FV on food consumption, according to the NOVA classification, among users of health promotion services in the Brazilian Primary Health Care (PHC). The outcomes analyzed were consumption of CP, processed foods (PF) and UPF through association and comparison analysis between CG and IG, and Generalized Estimating Equation (GEE) analysis. Article 3: ECCR which aimed to verify the effectiveness of a collective intervention to encourage the consumption of FV on the adequacy of nutrient intake for NCD prevention in health promotion service users of the Brazilian PHC. Association, comparison and GEE analyzes were also used between the GI and CG groups. The analyzed nutrients were total energy, carbohydrates, fiber, protein, total fat and fat subgroups: saturated, monounsaturated, polyunsaturated, trans, omega 3 and omega 6, vitamins A, B1, B2, B3, B6, B12, folate, C, D and E; and the minerals calcium, iron, phosphorus, magnesium, manganese, potassium, selenium, sodium and zinc. RESULTS - Article 1: The consumption of UPF contributed with 27.7% of the total energy of the diet. Its higher consumption was associated with higher values of energy intake, energy density, total fat and sodium; and smaller proteins, monounsaturated fats, omega 3 and some vitamins and minerals. The prevalence of inadequacy of nutrients for the NCD prevention ranged between 30% and 100% between the lowest and highest quintile of consumption of UPF. Article 2: After 12 months of follow-up, there was an increase in CP consumption and a reduction in UPF among individuals in the IG and CG; in addition to an increase in PF consumption among individuals in the CG. It was observed that the nutritional intervention contributed to a reduction in AP consumption for individuals allocated to the first quartile (RR: 0.861; CI: 0.749; 0.988) and an increase for those allocated to the second quartile of AP consumption (RR: 1,145; CI: 1,041; 1,259). A relationship was also observed between participation in the nutritional intervention and increased consumption of UPF for individuals in the third quartile of AUP consumption (RR: 1.062; CI: 1.005; 1.122). Article 3: Participants in the CG and IG groups, after 12 months, showed a reduction in the consumption of energy, omega 6 and sodium; and increased carbohydrates, fiber, vitamins A, B1, B2, B3, B6, B12, C, D and E, folate, calcium, magnesium, potassium, selenium, manganese, zinc and iron. Individuals from the CG showed an increase in phosphorus consumption; and those of the IG, reduction in the consumption of total, saturated and polyunsaturated fats; and increased monounsaturated. In both groups, there was an increase in the prevalence of nutrient adequacy for the NCD prevention, except for trans fats. Participation in nutritional intervention showed an inverse relationship with dietary energy (RR: 0,979; CI:0,960; 0,999) and protein intake (RR: 0,978; CI: 0,959; 0,997), but did not increase the chance of adequacy of nutrient intake for NCD prevention. CONCLUSION: The results pointed to the importance of the PAS, a health promotion service of the Unified Health System, for the promotion of adequate and healthy food, and NCD prevention. The conduction of collective intervention to encourage the consumption of FV showed few additional results, highlighting the need to carry out specific approaches related to the NOVA classification of foods in order to achieve better results.

Strategy of nutrition intervention on Duchenne muscular dystrophy / 中华临床营养杂志

Duchenne muscular dystrophy (DMD) is a fatal X-linked genetic disease caused by complete absence of Dystrophin due to mutation of DMD gene. Typical symptoms are progressive muscle loss which cause slow walking, gait abnormalities, falls, and difficult squatting. The adult patients often died from the respiratory and cardiovasucula failure in their early life stage.The early introduction of steroids has altered the natural history of the disease, but can exacerbate weight gain in a population already susceptible to obesity. Prior to commencing steroids, anticipatory guidance for weight management should be provided. Malnutrition is a feature of end stage disease requiring a multidisciplinary approach, such as texture modification and supplemental feeding. Micronutri- ent requirements are yet to be determined but, as a result of corticosteroid treatment, vitamin D and calcium should be supplemented. The multidisciplinary management of boys with DMD including nutrition treatment has progressed significantly and improved the life qulity of both patients and their parents.

Recomendaciones en el tratamiento nutricional para pacientes oncológicos ante Covid - 19 / Recommendations in the nutritional treatment for cancer patients before Covid ­ 19

Los pacientes con cáncer tienen alto riesgo de infección y muerte por Covid-19 tras exposición a dicho virus. En estos pacientes confluyen la edad avanzada, inmunodepresión, desnutrición, anemia, exposición a varios prestatarios de cuidados de salud durante el tratamiento citorreductor, estadía en hospitales y unidades cerradas, y los tiempos dilatados de los esquemas terapéuticos como factores de riesgo para desarrollar una infección por dicho virus. Esta revisión presenta recomendaciones sobre acciones requeridas para la identificación, evaluación del impacto sobre el estado de salud y la respuesta terapéutica, e intervención de la desnutrición presente en el paciente con cáncer. Las intervenciones alimentarias y nutricionales se adecúan a la etapa del tratamiento citorreductor, y las terapias empleadas, se orientan a la restauración de una inmunocompetencia requerida para prevención de la infección y la continuidad de los tratamientos antineoplásicos. Se prevén acciones nutricionales en aquellos pacientes con cáncer en caso de la ocurrencia de la Covid-19 a fin de preservar la vida del enfermo y prevenir complicaciones mayores. El presente manuscrito enfatiza las medidas de protección personal, familiar y ambiental contra la Covid-19 que son aplicables con iguales propósitos en el paciente con cáncer. El objetivo de esta revisión narrativa es proporcionar recomendaciones nutricionales claras para el paciente con cáncer en situaciones de alta vulnerabilidad inmunológica y nutricional, para lograr una disminución del riesgo de contagio viral con sus consecuentes complicaciones, asegurando así la continuidad de las acciones citorreductoras en el enfermo con cáncer.

Cancer patients are at high risk of infection and death from Covid-19 after exposure to this virus. In these patients, advanced age, immunosuppression, malnutrition, anemia, exposure to several health care providers during cytoreductive treatment, length of stay in hospitals and closed units, and lengthy therapeutic regimens converge as risk factors to developed an infection by Covid-19. This review presents recommendations on actions required for the identification, evaluation of the impact on the health status and therapeutic response, and intervention of malnutrition present in cancer patients. The food and nutritional interventions are adapted to the cytoreductive treatment stage, and the therapies used aim to restore the immunocompetence required for the prevention of infection and the continuity of antineoplastic treatments. Nutritional actions are foreseen in cancer patients with Covid-19 in order to preserve the life of the patient and prevent major complications. This manuscript emphasizes the personal, family, and environmental protection measures against Covid-19 that are applicable to the same purposes in cancer patients. This narrative review aims to provide clear nutritional recommendations for the cancer patient in high immunological and nutritional vulnerability to achieve a reduction in the risk of viral infection with its consequent complications, thus ensuring the continuity of cytoreductive actions in cancer patients.

Intervención nutricional participativa en adolescentes de enseñanza media del municipio Habana Vieja / Participative nutritional intervention in middle school adolescents from Habana Vieja municipality

Introducción: Los hábitos alimentarios no saludables potencian las enfermedades crónicas que constituyen las primeras causas de muerte en Cuba. Objetivos: Evaluar los efectos de una intervención nutricional sobre los cambios en los conocimientos de alimentación-nutrición y hábitos alimentarios en adolescentes. Métodos: Se realizó una intervención nutricional participativa con adolescentes de 12-15 años del municipio Habana Vieja, durante sus tres años curriculares. De los 604 adolescentes que comenzaron el estudio 155 formaron los grupos promotores que lideraron las actividades realizadas. Se aplicaron encuestas de conocimientos, consumo y hábitos alimentarios antes y después de la intervención. Para comparar la puntuación alcanzada se utilizó la prueba t de Student para muestras pareadas. Para la comparación entre escuelas se utilizó análisis de la varianza simple y para comparar los porcentajes de respuestas correctas de las preguntas de conocimientos, consumo de hortalizas y azúcar antes y después de la prueba de estimación de diferencias entre proporciones. Se definió como umbral de significación estadística p < 0,05. Resultados: Los grupos promotores mostraron aumentos significativos de los conocimientos (p < 0,001). Se encontraron diferencias entre escuelas para los grupos promotores (p < 0,001) y para el resto de los estudiantes (p = 0,024). Decreció el azúcar añadido a los refrescos para los grupos promotores (p < 0,001) y a la leche para todos los adolescentes (p = 0,002). No hubo cambios en el hábito de desayunar, en el gusto por alimentos fritos, ni en el consumo de refrescos, frituras, dulces y pizzas. Conclusiones: Las intervenciones de educación nutricional son necesarias para alcanzar patrones dietéticos más saludables y de esta manera contribuir a detener la epidemia de enfermedades no transmisibles, además permiten que los adolescentes tengan un acercamiento al tema alimentación-nutrición(AU)

Introduction: Non-healthy food habits boost chronic diseases that represent the main death causes in Cuba. Objectives: To assess the effects of a nutritional intervention on the changes in the knowledge of diet-nutrition and food habits of adolescents. Methods: It was carried out a participative nutritional intervention with adolescents from 12 to 15 years from Habana Vieja municipality during their 3 middle school years. From 604 adolescents that started the study, 155 formed the promoter groups which leadered the activities implemented. There were applied knowledge surveys on food consumption and habits before and after the intervention. For comparing the scores, it was used t-Student test for paired samples. It was used the analysis of simple variance for comparing among schools and the percentages of right answers in the knowledge questions, intake of vegetables and sugar before and after of the test for the estimation of differences among proportions. It was defined p<0,05 as the threshold of statistical signification. Results: The promoter groups showed significative increase of knowledge (p<0,001). There were found differences among schools for promoter groups (p<0,001) and for the rest of the students (p<0,024). In the promoter groups decreased the intake of sugar added to soft drinks (p<0,001) and to milk for all the adolescents studied (p<0,002). There were no changes in breakfast habits, liking fried food, or the consumption of soft drinks, fritters, sweets and pizzas. Conclusions: Nutritional education interventions are needed to reach healthier diet patterns and in this way contributing to stop the epidemic of non-communicable diseases; in addition, they allow adolescents to have an approach to food-nutrition topic(AU)

Combination Treatment with in Situ Tumor Vaccination Therapy and Nutritional Intervention Utilizing Lentinula Edodes Mycelia Extract for Patient with Lingual Cancer: A Case Report / 日本補完代替医療学会誌

In this report, we introduce the patient who show good prognosis after receiving combination therapy with in situ tumor vaccination therapy and nutritional intervention utilizing Lentinula Edodes Mycelia extract. In addition to the disease status, immune condition was also improved by combination therapy.

Intervenciones nutricionales para el tratamiento de la diabetes mellitus gestacional / Nutritional Interventions for the Treatment of Gestational Diabetes Mellitus / Intervenções nutricionais para o tratamento da diabetes mellitus gestacional

Resumen Introducción: la diabetes mellitus gestacional (DMG) es una alteración del metabolismo de los hidratos de carbono (HC), de severidad variable, que se inicia o se reconoce por primera vez durante la gestación; su frecuencia se ha duplicado en la última década en mujeres con factores de riesgo fácilmente identificables. La terapia de nutrición es una parte integral de la gestión de la DMG. Antiguamente, se utilizaba la restricción de HC; actualmente, se utiliza control de calidad y cantidad de HC, y se está evaluando la eficacia de distintas intervenciones nutricionales. Materiales y métodos: se realizó una búsqueda de artículos originales mediante PUBMED y bases académicas, principalmente ensayos clínicos en los que se demuestra el efecto de la intervención con distintos tipos de dietas en mujeres con DMG. Resultados: se obtuvieron mejores resultados en cuanto a los niveles de glucosa en las dietas altas en HC complejos, grasas saturadas y la utilización de proteína de soja, siendo estas una mejor opción para el control glucémico y evitar repercusiones en el estado nutrición de la madre y del bebé. Conclusión: la terapia nutricional basada en el control de la cantidad, calidad y distribución de HC es el tratamiento inicial para la DMG, pero existe la necesidad de ensayos controlados aleatorios que comparen diferentes intervenciones dietéticas y que evalúen modificaciones en porcentajes de macronutrimentos, valor calórico total, tipo y calidad de nutrimentos que demuestren el papel que cumple la intervención nutricional en los resultados de embarazos afectados con DMG.

Abstract Introduction: Gestational diabetes mellitus (GDM) is an alteration of carbohydrate metabolism, of variable severity, that is initiated or is recognized for the first time during gestation. Its frequency has doubled in the last decade, in women with easily identifiable risk factors. Nutrition therapy is an integral part of the management of GDM. Most women are treated only for nutritional management. The low carbohydrate diet is the most used. Material and methods: We searched original articles using PUBMED, SCI-HUB and academic groups, mainly articles of clinical trials demonstrating the efficacy of different types of diet applied to women with gestational diabetes and their impact on glucose. Results: Better glucose levels were obtained in the high diets in complex carbohydrates, unsaturated lipids and the use of soy protein, being these a better option for glicemic control and to avoid repercussions in the nutritional state of the mother and baby. Conclusion: Nutritional therapy based on quantity control and carbohydrate distribution is the initial treatment for gestational diabetes mellitus, but there is a need for randomized controlled trials comparing different dietary interventions modified in macronutrient percentages of total caloric value. Demonstrating the role they play in addition, Lipids and Proteins.

Resumo Introdução: a DMG é uma alteração do metabolismo dos hidratos de carbono (HC), de severidade variável, que se inicia ou se reconhece por primeira vez durante a gestação; sua frequência se tem duplicado na última década, em mulheres com fatores de risco facilmente identificáveis. A terapia de nutrição é uma parte integral da gestão da DMG. Antigamente utilizava-se a restrição de HC; atualmente se utiliza controle de qualidade e quantidade de HC, e está-se avaliando a eficácia de distintas intervenções nutricionais. Materiais e métodos: realizou-se uma busca de artigos originais mediante PUBMED e bases acadêmicas, principalmente ensaios clínicos nos que se demostra o efeito da intervenção com diferentes tipos de dietas em mulheres com DMG. Resultados: obtiveram-se melhores resultados em quanto aos níveis de glicose nas dietas altas em HC complexos, gorduras saturadas e a utilização de proteína de soja, sendo estas uma melhor opção para o controle glicêmico e evitar repercussões no estado nutricional da mãe e do bebê. Conclusão: a terapia de nutrição baseada no controle da quantidade, qualidade e distribuição de HC é o tratamento inicial para a DMG, mas existe a necessidade de ensaios controlados aleatórios que comparem diferentes intervenções dietéticas que avaliem modificações em porcentagens de ma-cronutrientes, valor calórico total, tipo e qualidade de nutrientes que demostrem o papel que tem a intervenção nutricional nos resultados de gravidezes afetadas com DMG.

Nutritional Intervention Process for a Patient with Kidney Transplantation: a Case Report

Renal transplantation is one of the renal replacement therapies for patients with end-stage renal disease. The number of patients who receive renal transplantation is continuously increasing, and the use of immunosuppressive drugs that are essential after transplantation requires continuous nutritional management. In the early post-transplantation period, sufficient supply of nutrition in consideration of the increase in metabolic demand is necessary. The long-term nutritional management after transplantation requires nutritional interventions to prevent obesity, hyperlipidemia, hypertension, diabetes, and osteoporosis, which are the adverse effects associated with the use of immunosuppressive drugs. Department of Dietetics in Samsung Medical Center has been engaging with patients to conduct them about initial nutritional assessment and reassessment, description of therapeutic diet, nutrition education for kidney transplantation, and follow-up education after discharge. Nutritional intervention of kidney transplant patients should be carried out according to the post-transplantation period and the nutritional status of the patient. It is necessary to perform patient management according to the planned process.

Effects of nutritional interventions based on nutritional risk assessment strategies on nutritional status and liver function in patients with cirrhosis / 中国实用护理杂志

Objective@#To investigate the effects of nutritional interventions based on nutritional risk assessment strategies on nutritional status and liver function in patients with cirrhosis.@*Methods@#Totally126 patients with cirrhosis admitted from July 2016 to October 2017 were enrolled. The prospective study was used and the patients were randomly divided into the treatment group and the control group with 63 cases in each group. The control group received routine nursing intervention, while the treatment group was combined nutritional intervention based on the nutritional risk assessment strategy. After 3 months of follow-up, serum nutrition indicators, liver function, and complications were compared between the two groups.@*Results@#The serum albumin, prealbumin and transferrin levels in the treatment group were (42.36±5.24) g/L, (0.37±0.08) g/L, and (3.01±0.42) g/L, which were significantly higher than those in the control group, which were (34.24±5.36) g/L, (0.30±0.07) g/L, (2.65±0.52) g/L (t=8.598, 5.227, 4.275, P<0.05 or 0.01); serum alanine aminotransferase and total bilirubin content were (95.32±12.45) μmol/L, (272.36±30.12) μmol/L, which were significantly lower than those of the control group [(114.21±13.20) μmol/L, (320.42±41.52) μmol/L]. The prothrombin time [(14.36±1.32) s] was significantly shorter than that of the control group [(16.12±1.20) s] (t=8.263, 7.437, 7.831, P<0.05); the complication rate of the treatment group was 7.94% (5/63), which was significantly lower than that of the control group (22.22%) (14/63)(χ2=5.020, P<0.05).@*Conclusions@#Nutrition intervention based on nutritional risk assessment strategy can improve nutritional status, relieve liver damage and reduce the incidence of complications such as peritonitis in liver cirrhosis patients.